Museums have the ability to educate and inspire visitors and to brighten a city's cultural landscape. However, when building a museum, project teams have several obstacles to overcome. Usually that involves accommodating cutting-edge design, but some project managers have contended with everything from flood recovery to violent political uprisings. This article discusses the biggest challenges faced by four museum megaprojects: Massar Children's Discovery Center (Damascus, Syria); Anchorage Museum (Anchorage, Alaska); Carpathian Troy Open-Air Museum (Trzcinica, Poland); and Soumay Museum (Mexico City, Mexico). It also identifies how the project teams handled these challenges.